GDNF

Across TCGA cell cohorts, GDNF mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible GDNF-associated genes across cancer lineages are OR6F1, OR5H2, and MMD2. Each is linked with GDNF in more than 1 cancer types. Because this analysis shows association rather than direction, both GDNF-to-partner and partner-to-GDNF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR6F1 grouped by GDNF-low versus GDNF-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GDNF→partner) and Y-score (partner→GDNF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	OR6F1 →	+0.068	+4.421	<.001	.004	3	1
BREAST	OR5H2 →	+0.022	+4.781	<.001	.003	3	1
UPPER_AERODIGESTIVE_TRACT	MMD2 →	+0.036	+4.736	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	UTF1 →	+0.226	+5.357	<.001	.003	3	1
UPPER_AERODIGESTIVE_TRACT	PRR23C →	+0.006	+4.736	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	USP17L22 →	+0.013	+5.357	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

OR6F1 by GDNF expression — BREAST

Explore this box plot interactively →