GDNF-AS1

Across TCGA pan-cancer cohorts, GDNF-AS1 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated GDNF-AS1 data layer.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher GDNF-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated GDNF-AS1 expression acts as an unfavorable survival marker, although some lineages such as LGG and CESC show a favorable association.

ACC, MESO, and KIRP are the cancer types where GDNF-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.348	0.767	<.001	129	view →
MESO	OS	Median	All	0.415	0.681	<.001	87	view →
KIRP	OS	Tertile	All	0.523	0.822	<.001	85	view →
LGG	OS	Median	All	0.527	0.368	<.001	53	view →
CESC	DFS	Quartile	IV	0.764	0.252	.006	30	view →
SKCM	OS	Quartile	All	0.436	0.221	.001	26	view →
CHOL	DFS	Median	II,III,IV	0.121	0.626	.002	25	view →
LIHC	OS	Tertile	III,IV	0.871	0.466	<.001	25	view →
PAAD	DFS	Tertile	All	0.626	0.444	.010	18	view →
KIRC	DFS	Quartile	All	0.565	0.703	.009	15	view →
OV	OS	Median	IV	0.573	0.902	<.001	12	view →
DLBC	OS	Median	III,IV	0.272	1.000	.017	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

GDNF-AS1–ACC (DFS)

Open the ACC breakdown →