GDI2

Across TCGA patient cohorts, GDI2 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GDI2-associated genes across cancer lineages are C-Raf, EGFR_pY1068, and eIF4G. Each is linked with GDI2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GDI2-to-partner and partner-to-GDI2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by GDI2-low versus GDI2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GDI2→partner) and Y-score (partner→GDI2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.257	+3.807	<.001	<.001	3	2
UCEC	EGFR_pY1068 →	-0.336	-3.459	.001	.005	3	1
UCEC	eIF4G →	+0.356	+3.321	.005	.009	3	1
UCEC	ERK2 →	+0.233	+3.169	.003	.018	3	1
UCEC	FoxM1 →	+0.271	+1.807	.011	.027	3	1
UCEC	FOXO3a_pS318_S321 →	-0.113	-2.105	.028	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

C-Raf by GDI2 expression — UCEC

Explore this box plot interactively →