GDI2

Across TCGA cell cohorts, GDI2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,475 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible GDI2-associated GO terms across cancer lineages are Positive regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, DNA replication initiation, and Lagging strand elongation. Each is linked with GDI2 in more than 12 cancer types. Because this analysis shows association rather than direction, both GDI2-to-partner and partner-to-GDI2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay grouped by GDI2-low versus GDI2-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GDI2→partner) and Y-score (partner→GDI2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Positive regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay →	+0.153	+1.101	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	DNA replication initiation →	+0.133	+0.976	.003	.003	2	13
BLOOD_Lymphoma	Lagging strand elongation →	+0.132	+0.964	<.001	<.001	3	12
LUNG_SCLC	DAMP biosynthetic process →	+0.131	+0.680	.003	.008	3	11
LUNG_SCLC	Purine deoxyribonucleoside monophosphate biosynthetic process →	+0.131	+0.680	.003	.008	3	11
UPPER_AERODIGESTIVE_TRACT	Positive regulation of mitochondrial ATP synthesis coupled electron transport →	+0.125	+1.126	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,475 associations by consensus.

Positive regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay by GDI2 expression — LUNG_NSCLC_LUSC

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