Across TCGA patient cohorts, GDI1 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GDI1-associated genes across cancer lineages are Rab11, STAT3_pY705, and ATM. Each is linked with GDI1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GDI1-to-partner and partner-to-GDI1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GDI1→partner) and Y-score (partner→GDI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rab11 →	-0.131	-2.058	.004	<.001	3	2
UCEC	STAT3_pY705 →	-0.316	-1.523	<.001	.008	3	2
UCEC	ATM →	-0.384	-2.102	.008	.016	3	2
UCEC	EGFR_pY1068 →	-0.248	-1.289	.001	.023	3	1
UCEC	eIF4E →	+0.134	+2.598	.046	.005	3	1
UCEC	eIF4G →	+0.225	+1.874	.023	.049	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

Exploration

GDI1 survival (RNA) · tumor vs normal (RNA) · all GDI1 data types