GDF6

Across TCGA patient cohorts, GDF6 mutation is significantly associated with the RNA expression of many other genes, with 3,347 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GDF6-associated genes across cancer lineages are TYMS, DLAT, and HAUS1. Each is linked with GDF6 in more than 3 cancer types. Because this analysis shows association rather than direction, both GDF6-to-partner and partner-to-GDF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TYMS grouped by GDF6-low versus GDF6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GDF6→partner) and Y-score (partner→GDF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TYMS →	+0.615	+3.375	.004	.004	3	4
STAD	DLAT →	+0.850	+3.236	<.001	.009	3	3
UCEC	HAUS1 →	+0.440	+2.032	.004	<.001	3	3
UCEC	DFFA →	+0.530	+2.375	<.001	<.001	3	3
UCEC	PKN3 →	+0.571	+2.332	<.001	<.001	3	3
UCEC	PGAM1 →	+0.734	+3.828	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,347 associations by consensus.

TYMS by GDF6 expression — UCEC

Explore this box plot interactively →