GDF6

Across TCGA cell cohorts, GDF6 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,416 significant associations in total. BONE shows the largest number of these associations.

The most reproducible GDF6-associated GO terms across cancer lineages are Endoplasmic reticulum to Golgi vesicle-mediated transport, Protein folding, and Establishment of protein localization to membrane. Each is linked with GDF6 in more than 7 cancer types. Because this analysis shows association rather than direction, both GDF6-to-partner and partner-to-GDF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Endoplasmic reticulum to Golgi vesicle-mediated transport grouped by GDF6-low versus GDF6-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GDF6→partner) and Y-score (partner→GDF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Endoplasmic reticulum to Golgi vesicle-mediated transport →	+0.065	+2.355	.002	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	Protein folding →	+0.063	+0.297	<.001	.004	3	7
LUNG_NSCLC_LUAD	Establishment of protein localization to membrane →	+0.029	+0.342	.001	.002	3	7
BONE	Purine nucleoside triphosphate biosynthetic process →	+0.097	+3.484	.004	.001	3	6
BONE	Purine ribonucleoside triphosphate biosynthetic process →	+0.097	+3.484	.004	.001	3	6
LUNG_NSCLC_LUSC	Protein localization to nucleus →	+0.038	+0.239	.001	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,416 associations by consensus.

Endoplasmic reticulum to Golgi vesicle-mediated transport by GDF6 expression — KIDNEY

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