GDF6

Across TCGA cell cohorts, GDF6 mutation is significantly associated with the RNA expression of many other genes, with 356 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GDF6-associated genes across cancer lineages are OR5G3, MAGEB4, and GJD2. Each is linked with GDF6 in more than 1 cancer types. Because this analysis shows association rather than direction, both GDF6-to-partner and partner-to-GDF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR5G3 grouped by GDF6-low versus GDF6-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GDF6→partner) and Y-score (partner→GDF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	OR5G3 →	+0.030	+4.321	<.001	<.001	3	2
LARGE_INTESTINE	MAGEB4 →	+0.008	+2.830	.001	.004	3	2
UPPER_AERODIGESTIVE_TRACT	GJD2 →	+0.033	+3.917	.003	.004	3	1
SKIN	CIB4 →	+0.038	+4.415	<.001	.007	3	1
SKIN	INSL5 →	+0.053	+4.467	<.001	.004	3	1
SKIN	GPR139 →	+0.042	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 356 associations by consensus.

OR5G3 by GDF6 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →