GDF5

Across TCGA pan-cancer cohorts, GDF5 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated GDF5 data layer compared with 24 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher GDF5 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated GDF5 expression acts as an unfavorable survival marker.

PDAC, UCEC, and CCRCC are the cancer types where GDF5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	All	0.294	0.792	.001	81	view →
UCEC	OS	Tertile	III,IV	0.286	1.000	.013	28	view →
CCRCC	DFS	Median	All	0.624	0.899	.034	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

GDF5–PDAC (OS)

Open the PDAC breakdown →