GDF5

Across TCGA patient cohorts, GDF5 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. COAD shows the largest number of these associations.

The most reproducible GDF5-associated genes across cancer lineages are PKC-a, GAPDH, and 4E-BP1_pS65. Each is linked with GDF5 in more than 2 cancer types. Because this analysis shows association rather than direction, both GDF5-to-partner and partner-to-GDF5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKC-a grouped by GDF5-low versus GDF5-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GDF5→partner) and Y-score (partner→GDF5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PKC-a →	-0.338	-3.000	.010	.035	3	3
SKCM	GAPDH →	+0.504	+2.700	.018	.005	3	3
SKCM	4E-BP1_pS65 →	+0.160	+2.820	.028	.001	3	3
COAD	PREX1 →	+0.213	+2.195	.029	.034	3	2
COAD	Smad4 →	+0.224	+3.330	<.001	.005	3	2
COAD	STAT5a →	-0.544	-2.987	.034	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

PKC-a by GDF5 expression — COAD

Explore this box plot interactively →