GDF5

Across TCGA cell cohorts, GDF5 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,891 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible GDF5-associated GO terms across cancer lineages are Positive regulation of cell-substrate junction organization, Positive regulation of protein K48-linked ubiquitination, and Positive regulation of focal adhesion assembly. Each is linked with GDF5 in more than 8 cancer types. Because this analysis shows association rather than direction, both GDF5-to-partner and partner-to-GDF5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of cell-substrate junction organization grouped by GDF5-low versus GDF5-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GDF5→partner) and Y-score (partner→GDF5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Positive regulation of cell-substrate junction organization →	+0.083	+0.875	<.001	.006	3	9
BREAST	Positive regulation of protein K48-linked ubiquitination →	+0.165	+0.667	<.001	.004	3	8
CNS	Positive regulation of focal adhesion assembly →	+0.112	+1.836	<.001	<.001	3	8
CNS	Regulation of cell-substrate junction organization →	+0.059	+2.026	<.001	<.001	3	8
LUNG_NSCLC_LUAD	PML body organization →	+0.132	+0.542	<.001	.007	3	8
CNS	Regulation of cell-substrate junction assembly →	+0.060	+1.496	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,891 associations by consensus.

Positive regulation of cell-substrate junction organization by GDF5 expression — SOFT_TISSUE

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