Across TCGA patient cohorts, GDF5-AS1 mutation is significantly associated with the RNA expression of many other genes, with 61 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GDF5-AS1-associated genes across cancer lineages are MIR549A, RNA5SP436, and MIR5697. Each is linked with GDF5-AS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GDF5-AS1-to-partner and partner-to-GDF5-AS1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GDF5-AS1→partner) and Y-score (partner→GDF5-AS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	MIR549A →	+0.453	+6.342	<.001	.001	3	2
UCEC	RNA5SP436 →	+0.758	+4.522	<.001	<.001	3	2
UCEC	MIR5697 →	+0.493	+3.303	.004	.004	3	2
UCEC	BNIP3P4 →	+0.136	+4.069	<.001	.002	3	1
UCEC	MIR98 →	+0.370	+3.386	.002	.008	3	1
UCEC	MIR4727 →	+0.548	+4.136	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 61 associations by consensus.

Exploration

GDF5-AS1 survival (RNA) · tumor vs normal (RNA) · all GDF5-AS1 data types