Across TCGA patient cohorts, GDF3 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GDF3-associated genes across cancer lineages are Bak, Cyclin-B1, and Rad50. Each is linked with GDF3 in more than 1 cancer types. Because this analysis shows association rather than direction, both GDF3-to-partner and partner-to-GDF3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GDF3→partner) and Y-score (partner→GDF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Bak →	+0.236	+2.000	.014	.029	3	2
UCEC	Cyclin-B1 →	+0.575	+2.000	.007	.030	3	2
SKCM	Rad50 →	-0.231	-1.584	.026	.018	3	2
UCEC	EGFR_pY1068 →	-0.317	-3.247	<.001	<.001	3	1
UCEC	EGFR_pY1173 →	+0.062	+2.114	.042	.003	3	1
UCEC	A-Raf_pS299 →	-0.144	-3.584	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Exploration

GDF3 survival (RNA) · tumor vs normal (RNA) · all GDF3 data types