Across TCGA cell cohorts, GDF3 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. OESOPHAGUS shows the largest number of these associations.

The most reproducible GDF3-associated genes across cancer lineages are CRYGA, SMIM23, and MTRNR2L10. Each is linked with GDF3 in more than 1 cancer types. Because this analysis shows association rather than direction, both GDF3-to-partner and partner-to-GDF3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GDF3→partner) and Y-score (partner→GDF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	CRYGA →	+0.043	+4.906	<.001	.006	3	1
OESOPHAGUS	SMIM23 →	+0.023	+4.906	<.001	.006	3	1
OESOPHAGUS	MTRNR2L10 →	+0.006	+4.906	<.001	.006	3	1
LARGE_INTESTINE	OR2M5 →	+0.021	+4.415	<.001	.007	3	1
LARGE_INTESTINE	ACCSL →	+0.028	+4.273	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Exploration

GDF3 survival (RNA) · tumor vs normal (RNA) · all GDF3 data types