GDF2

Across TCGA patient cohorts, GDF2 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,535 significant associations in total. STAD shows the largest number of these associations.

The most reproducible GDF2-associated GO terms across cancer lineages are Regulation of actin filament organization, Peptide transport, and Protein stabilization. Each is linked with GDF2 in more than 8 cancer types. Because this analysis shows association rather than direction, both GDF2-to-partner and partner-to-GDF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of actin filament organization grouped by GDF2-low versus GDF2-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GDF2→partner) and Y-score (partner→GDF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Regulation of actin filament organization →	+0.085	+0.043	<.001	<.001	3	9
STAD	Peptide transport →	+0.054	+0.041	<.001	<.001	3	9
STAD	Protein stabilization →	+0.098	+0.045	<.001	<.001	3	8
STAD	Monocarboxylic acid catabolic process →	+0.069	+0.043	<.001	<.001	3	8
STAD	Protein localization to plasma membrane →	+0.091	+0.047	<.001	<.001	3	8
STAD	Negative regulation of supramolecular fiber organization →	+0.076	+0.041	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,535 associations by consensus.

Regulation of actin filament organization by GDF2 expression — STAD

Explore this box plot interactively →