GDF2

Across TCGA patient cohorts, GDF2 mutation is significantly associated with the RNA expression of many other genes, with 4,719 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GDF2-associated genes across cancer lineages are EIF2B2, YARS1, and BCCIP. Each is linked with GDF2 in more than 3 cancer types. Because this analysis shows association rather than direction, both GDF2-to-partner and partner-to-GDF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EIF2B2 grouped by GDF2-low versus GDF2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GDF2→partner) and Y-score (partner→GDF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EIF2B2 →	+0.343	+2.032	<.001	<.001	3	4
UCEC	YARS1 →	+0.507	+1.808	<.001	<.001	3	4
SKCM	BCCIP →	+0.481	+2.100	.001	.002	3	3
SKCM	GLRX3 →	+0.479	+2.194	.001	<.001	3	3
UCEC	LRRC59 →	+0.615	+2.010	<.001	<.001	3	3
SKCM	ITFG2 →	-0.428	-1.762	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,719 associations by consensus.

EIF2B2 by GDF2 expression — UCEC

Explore this box plot interactively →