GDF2

Across TCGA cell cohorts, GDF2 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible GDF2-associated genes across cancer lineages are OR4D6, OR51T1, and OR9A2. Each is linked with GDF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GDF2-to-partner and partner-to-GDF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4D6 grouped by GDF2-low versus GDF2-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GDF2→partner) and Y-score (partner→GDF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	OR4D6 →	+0.018	+5.209	.002	.005	3	1
BLOOD_Lymphoma	OR51T1 →	+0.029	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	OR9A2 →	+0.032	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	OR5W2 →	+0.019	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	RNASE9 →	+0.019	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	PRAMEF25 →	+0.011	+4.867	.009	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

OR4D6 by GDF2 expression — BLOOD_Lymphoma

Explore this box plot interactively →