GDF15

Across TCGA pan-cancer cohorts, GDF15 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated GDF15 data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher GDF15 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated GDF15 expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

COAD, LUAD, and PDAC are the cancer types where GDF15 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	0.912	1.000	.030	12	view →
LUAD	DFS	Tertile	All	0.844	0.964	.004	10	view →
PDAC	DFS	Quartile	III,IV	0.299	1.000	.024	6	view →
HNSC	OS	Median	All	0.645	1.000	.018	5	view →
LSCC	OS	Median	All	0.695	0.872	.013	3	view →
CCRCC	OS	Tertile	IV	1.000	0.204	.036	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

GDF15–COAD (DFS)

Open the COAD breakdown →