GDF15

Across TCGA patient cohorts, GDF15 RNA expression is significantly associated with the protein abundance of many other proteins, with 12,338 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible GDF15-associated proteins across cancer lineages are ARFGEF3, PGPEP1, and MISP3_S91. Each is linked with GDF15 in more than 4 cancer types. Because this analysis shows association rather than direction, both GDF15-to-partner and partner-to-GDF15 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GDF15 versus ARFGEF3 in BRCA, with a Pearson correlation of 0.47.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (GDF15→partner) and Y-score (partner→GDF15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ARFGEF3 →	+0.464	+1.350	<.001	<.001	3	5
BRCA	PGPEP1 →	+0.394	+1.039	<.001	<.001	3	5
PDAC	MISP3_S91 →	+0.758	+1.095	<.001	.001	3	5
PDAC	MTFR1L_S110 →	+0.604	+0.981	<.001	<.001	3	4
GBM	PHKA1_S758 →	+0.769	+1.280	<.001	<.001	3	4
GBM	ASL →	+0.321	+1.187	.005	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,338 associations by consensus.

GDF15 vs ARFGEF3 — BRCA

Explore this scatter interactively →