GDF15

Across TCGA patient cohorts, GDF15 protein abundance is significantly associated with the RNA expression of many other genes, with 5,108 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible GDF15-associated genes across cancer lineages are MIR3189, TIMP1, and BNIP2. Each is linked with GDF15 in more than 5 cancer types. Because this analysis shows association rather than direction, both GDF15-to-partner and partner-to-GDF15 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GDF15 versus MIR3189 in UCEC, with a Pearson correlation of 0.27.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GDF15→partner) and Y-score (partner→GDF15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR3189 →	+1.522	+0.585	.004	.006	2	6
GBM	TIMP1 →	+1.803	+0.786	<.001	<.001	3	3
PDAC	BNIP2 →	-0.430	-0.531	<.001	<.001	3	3
OV	LRRC49 →	+0.787	+1.029	.004	.007	3	2
OV	TRDC →	-2.440	-0.881	<.001	.004	3	2
HNSC	FOXL1 →	+0.909	+0.819	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,108 associations by consensus.

GDF15 vs MIR3189 — UCEC

Explore this scatter interactively →