GDF15

Across TCGA patient cohorts, GDF15 mutation is significantly associated with the RNA expression of many other genes, with 67 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible GDF15-associated genes across cancer lineages are RNA5SP72, RNU6-362P, and RNU6-774P. Each is linked with GDF15 in more than 1 cancer types. Because this analysis shows association rather than direction, both GDF15-to-partner and partner-to-GDF15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP72 grouped by GDF15-low versus GDF15-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GDF15→partner) and Y-score (partner→GDF15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNA5SP72 →	+0.416	+5.038	<.001	.009	3	2
STAD	RNU6-362P →	+0.436	+4.520	<.001	.005	3	2
LUSC	RNU6-774P →	+0.386	+4.984	.001	.009	3	2
LUSC	MTND4LP20 →	+0.188	+6.733	<.001	<.001	3	2
LUSC	LINC01853 →	+0.809	+5.978	<.001	.002	3	2
LUSC	MIR3908 →	+0.409	+5.882	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 67 associations by consensus.

RNA5SP72 by GDF15 expression — LUSC

Explore this box plot interactively →