GDF15

Across TCGA cell cohorts, GDF15 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,043 significant associations in total. BONE shows the largest number of these associations.

The most reproducible GDF15-associated GO terms across cancer lineages are GDF15-GFRAL signaling pathway, Reduction of food intake in response to dietary excess, and Regulation of growth hormone receptor signaling pathway. Each is linked with GDF15 in more than 19 cancer types. Because this analysis shows association rather than direction, both GDF15-to-partner and partner-to-GDF15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GDF15-GFRAL signaling pathway grouped by GDF15-low versus GDF15-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GDF15→partner) and Y-score (partner→GDF15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	GDF15-GFRAL signaling pathway →	+1.684	+3.265	<.001	<.001	3	20
BREAST	Reduction of food intake in response to dietary excess →	+1.731	+3.990	<.001	<.001	3	20
LIVER	Regulation of growth hormone receptor signaling pathway →	+0.225	+3.574	.001	.005	3	17
URINARY_TRACT	Glial cell-derived neurotrophic factor receptor signaling pathway →	+1.420	+3.894	.001	<.001	3	16
OESOPHAGUS	Negative regulation of multicellular organism growth →	+0.241	+3.857	<.001	<.001	3	15
LIVER	Negative regulation of growth hormone receptor signaling pathway →	+0.227	+3.095	.002	.007	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,043 associations by consensus.

GDF15-GFRAL signaling pathway by GDF15 expression — BLOOD_Myeloma

Explore this box plot interactively →