GDF11

Across TCGA patient cohorts, GDF11 RNA expression is significantly associated with the protein abundance of many other proteins, with 18,827 significant associations in total. GBM shows the largest number of these associations.

The most reproducible GDF11-associated proteins across cancer lineages are ABI2_S227, HDAC2, and MYG1. Each is linked with GDF11 in more than 5 cancer types. Because this analysis shows association rather than direction, both GDF11-to-partner and partner-to-GDF11 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GDF11 versus ABI2_S227 in HNSC, with a Pearson correlation of 0.39.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (GDF11→partner) and Y-score (partner→GDF11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ABI2_S227 →	+0.575	+0.569	.001	.001	3	6
HNSC	HDAC2 →	+0.313	+0.662	<.001	<.001	3	6
OV	MYG1 →	+0.306	+1.037	.002	<.001	3	6
OV	PSME2 →	-0.397	-0.773	<.001	<.001	3	6
GBM	SMARCC2 →	+0.213	+0.383	<.001	<.001	3	6
GBM	PARP4 →	-0.433	-0.566	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,827 associations by consensus.

GDF11 vs ABI2_S227 — HNSC

Explore this scatter interactively →