GDF11

Across TCGA patient cohorts, GDF11 protein abundance is significantly associated with the RNA expression of many other genes, with 3,167 significant associations in total. GBM shows the largest number of these associations.

The most reproducible GDF11-associated genes across cancer lineages are EEF2, ZC3H7B, and A1BG-AS1. Each is linked with GDF11 in more than 2 cancer types. Because this analysis shows association rather than direction, both GDF11-to-partner and partner-to-GDF11 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GDF11 versus EEF2 in LUAD, with a Pearson correlation of 0.82.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GDF11→partner) and Y-score (partner→GDF11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	EEF2 →	+0.860	+0.631	.008	<.001	3	3
LUAD	ZC3H7B →	+0.583	+0.631	.003	<.001	3	2
LUAD	A1BG-AS1 →	+0.738	+0.831	.006	<.001	3	2
LUAD	CRYBB3 →	+1.093	+0.693	<.001	.001	3	1
LUAD	HDAC10 →	+0.260	+0.631	.008	<.001	3	1
LUAD	TULP2 →	+0.456	+0.631	.002	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,167 associations by consensus.

GDF11 vs EEF2 — LUAD

Explore this scatter interactively →