GDF11

Across TCGA patient cohorts, GDF11 mutation is significantly associated with the immune_cell of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GDF11-associated genes across cancer lineages are cDC, Adipocytes, and DC. Each is linked with GDF11 in more than 1 cancer types. Because this analysis shows association rather than direction, both GDF11-to-partner and partner-to-GDF11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, cDC grouped by GDF11-low versus GDF11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GDF11→partner) and Y-score (partner→GDF11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	cDC →	+0.147	+3.178	<.001	.010	3	1
UCEC	Adipocytes →	+0.021	+2.729	.013	.009	3	1
UCEC	DC →	+0.022	+2.255	.027	.009	3	1
UCEC	Macrophages M2 →	+0.011	+1.855	.023	.047	3	1
UCEC	Th2 cells →	+0.291	+3.177	<.001	.010	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

cDC by GDF11 expression — UCEC

Explore this box plot interactively →