GDF11

Across TCGA cell cohorts, GDF11 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. CNS shows the largest number of these associations.

The most reproducible GDF11-associated genes across cancer lineages are MYF5 and CCER1. Each is linked with GDF11 in more than 1 cancer types. Because this analysis shows association rather than direction, both GDF11-to-partner and partner-to-GDF11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYF5 grouped by GDF11-low versus GDF11-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GDF11→partner) and Y-score (partner→GDF11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	MYF5 →	+0.749	+5.321	<.001	.005	3	1
CNS	CCER1 →	+0.016	+5.754	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

MYF5 by GDF11 expression — CNS

Explore this box plot interactively →