GDF1

Across TCGA patient cohorts, GDF1 protein abundance is significantly associated with the RNA expression of many other genes, with 4,744 significant associations in total. GBM shows the largest number of these associations.

The most reproducible GDF1-associated genes across cancer lineages are TTYH2, PFKFB4, and SOX4. Each is linked with GDF1 in more than 3 cancer types. Because this analysis shows association rather than direction, both GDF1-to-partner and partner-to-GDF1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GDF1 versus TTYH2 in GBM, with a Pearson correlation of 0.74.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GDF1→partner) and Y-score (partner→GDF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TTYH2 →	+0.896	+0.630	<.001	<.001	3	4
LUAD	PFKFB4 →	-1.029	-0.417	<.001	<.001	3	3
BRCA	SOX4 →	-1.219	-0.636	<.001	.002	3	3
HNSC	TGFBI →	-1.769	-0.338	<.001	.009	3	3
LSCC	ALDH2 →	+0.591	+0.287	.001	.002	3	2
GBM	TFEB →	+0.397	+0.393	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,744 associations by consensus.

GDF1 vs TTYH2 — GBM

Explore this scatter interactively →