GDF1

Across TCGA cell cohorts, GDF1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,511 significant associations in total. BONE shows the largest number of these associations.

The most reproducible GDF1-associated GO terms across cancer lineages are DNA-templated transcription initiation, SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, and tRNA transcription. Each is linked with GDF1 in more than 12 cancer types. Because this analysis shows association rather than direction, both GDF1-to-partner and partner-to-GDF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA-templated transcription initiation grouped by GDF1-low versus GDF1-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GDF1→partner) and Y-score (partner→GDF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	DNA-templated transcription initiation →	+0.096	+0.605	<.001	.003	3	13
OESOPHAGUS	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process →	+0.082	+0.602	<.001	<.001	3	13
OESOPHAGUS	tRNA transcription →	+0.122	+0.685	<.001	<.001	3	12
OESOPHAGUS	Transcription initiation at RNA polymerase II promoter →	+0.080	+0.465	<.001	.001	3	12
OESOPHAGUS	Renal vesicle formation →	+1.451	+0.470	<.001	.001	3	11
OESOPHAGUS	Metanephric renal vesicle formation →	+1.451	+0.470	<.001	.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,511 associations by consensus.

DNA-templated transcription initiation by GDF1 expression — OESOPHAGUS

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