GDF1

Across TCGA cell cohorts, GDF1 mutation is significantly associated with the RNA expression of many other genes, with 43 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible GDF1-associated genes across cancer lineages are LY6H, PRAMEF17, and OR2H1. Each is linked with GDF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GDF1-to-partner and partner-to-GDF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LY6H grouped by GDF1-low versus GDF1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GDF1→partner) and Y-score (partner→GDF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	LY6H →	+0.185	+4.095	<.001	.009	3	1
SKIN	PRAMEF17 →	+0.012	+5.022	<.001	.002	3	1
SKIN	OR2H1 →	+0.021	+4.273	.004	.006	3	1
SKIN	NEXMIF →	+0.149	+4.095	<.001	.009	3	1
SKIN	TFAP2D →	+0.142	+4.415	<.001	.007	3	1
BLOOD_Lymphoma	PPP1R2C →	+0.278	+4.452	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

LY6H by GDF1 expression — SKIN

Explore this box plot interactively →