GDAP1

Across TCGA pan-cancer cohorts, GDAP1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated GDAP1 data layer compared with 23 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher GDAP1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated GDAP1 expression acts as an unfavorable survival marker, although some lineages such as GBM and PDAC show a favorable association.

HNSC, UCEC, and CCRCC are the cancer types where GDAP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	0.284	0.832	.008	37	view →
UCEC	OS	Median	III,IV	0.433	1.000	.007	26	view →
CCRCC	DFS	Quartile	II,III,IV	0.440	0.801	.010	12	view →
GBM	DFS	Median	All	0.470	0.279	.010	10	view →
PDAC	OS	Median	IV	0.937	0.395	.026	5	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

GDAP1–HNSC (DFS)

Open the HNSC breakdown →