GDAP1

Across TCGA patient cohorts, GDAP1 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GDAP1-associated genes across cancer lineages are Cyclin-B1, EGFR_pY1068, and GSK-3_pS9. Each is linked with GDAP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GDAP1-to-partner and partner-to-GDAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by GDAP1-low versus GDAP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GDAP1→partner) and Y-score (partner→GDAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.615	+2.584	.018	.011	3	2
UCEC	EGFR_pY1068 →	-0.294	-2.584	.012	.011	3	1
UCEC	GSK-3_pS9 →	-0.678	-3.169	<.001	.018	3	1
UCEC	MAPK_pT202_Y204 →	-0.482	-2.986	.027	.035	3	1
UCEC	p62 Lck ligand →	+0.384	+3.009	.011	.019	3	1
UCEC	PKC-a_pS657 →	+0.491	+2.598	.005	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Cyclin-B1 by GDAP1 expression — UCEC

Explore this box plot interactively →