GDA

Across TCGA cell cohorts, GDA mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GDA-associated genes across cancer lineages are SSMEM1, OR1L6, and TFDP3. Each is linked with GDA in more than 1 cancer types. Because this analysis shows association rather than direction, both GDA-to-partner and partner-to-GDA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SSMEM1 grouped by GDA-low versus GDA-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GDA→partner) and Y-score (partner→GDA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SSMEM1 →	+0.030	+3.707	<.001	.009	3	1
LARGE_INTESTINE	OR1L6 →	+0.022	+4.437	<.001	.004	3	1
LARGE_INTESTINE	TFDP3 →	+0.037	+4.196	<.001	.002	3	1
LARGE_INTESTINE	CENPVL1 →	+0.182	+4.510	<.001	.001	3	1
LARGE_INTESTINE	CENPVL3 →	+0.335	+3.920	<.001	.005	3	1
LARGE_INTESTINE	NEXMIF →	+0.338	+4.196	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

SSMEM1 by GDA expression — LARGE_INTESTINE

Explore this box plot interactively →