GCSH

Across TCGA patient cohorts, GCSH mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GCSH-associated genes across cancer lineages are eIF4E, PDK1_pS241, and Annexin-1. Each is linked with GCSH in more than 1 cancer types. Because this analysis shows association rather than direction, both GCSH-to-partner and partner-to-GCSH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by GCSH-low versus GCSH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GCSH→partner) and Y-score (partner→GCSH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.221	+2.820	.045	.035	3	1
UCEC	PDK1_pS241 →	+0.182	+2.183	.042	.035	3	1
UCEC	Annexin-1 →	+0.761	+3.189	.005	.010	3	1
UCEC	Bad_pS112 →	-0.261	-3.000	.007	.036	3	1
UCEC	TIGAR →	+0.176	+3.348	.027	.005	2	1
UCEC	Caspase-8 →	-0.290	-3.321	.028	.010	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

eIF4E by GCSH expression — UCEC

Explore this box plot interactively →