GCOM1

Across TCGA pan-cancer cohorts, GCOM1 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated GCOM1 data layer compared with 1 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher GCOM1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated GCOM1 expression acts as an unfavorable survival marker, although some lineages such as BRCA and ESCA show a favorable association.

CESC, LUSC, and LGG are the cancer types where GCOM1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Median	All	0.463	0.725	<.001	64	view →
LUSC	DFS	Median	All	0.319	0.460	<.001	58	view →
LGG	OS	Median	All	0.726	0.873	<.001	54	view →
BRCA	DFS	Tertile	III,IV	0.944	0.779	<.001	45	view →
OV	OS	Tertile	All	0.291	0.382	.025	36	view →
ESCA	OS	Tertile	III,IV	0.717	0.326	<.001	24	view →
UCEC	OS	Quartile	All	0.891	0.943	.003	24	view →
MESO	OS	Tertile	IV	0.312	0.850	.008	15	view →
LIHC	OS	Quartile	III,IV	0.321	0.636	.010	11	view →
SKCM	OS	Median	II,III,IV	0.628	0.781	.019	10	view →
LUAD	DFS	Tertile	All	0.194	0.488	.013	10	view →
TGCT	DFS	Median	All	0.914	0.749	.015	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

GCOM1–CESC (OS)

Open the CESC breakdown →