GCNAP1

Across TCGA pan-cancer cohorts, GCNAP1 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of GCNAP1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where GCNAP1 RNA is repressed in tumor relative to normal tissue. In most cancer types GCNAP1 is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, THCA, and PRAD are the cancer types where GCNAP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GCNAP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	−0.067	.006	3	view →
THCA	Female	II,III,IV	−0.121	.017	2	view →
PRAD	All	All	−0.049	.042	2	view →
LUAD	All	All	+0.190	.011	1	view →
LUSC	All	All	+0.081	.044	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

GCNAP1–KIRC

Open the KIRC breakdown →