GCNA

Across TCGA patient cohorts, GCNA mutation is significantly associated with the RNA expression of many other genes, with 2,487 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GCNA-associated genes across cancer lineages are RPL23AP39, RNU7-29P, and RNA5SP172. Each is linked with GCNA in more than 2 cancer types. Because this analysis shows association rather than direction, both GCNA-to-partner and partner-to-GCNA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL23AP39 grouped by GCNA-low versus GCNA-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GCNA→partner) and Y-score (partner→GCNA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RPL23AP39 →	+0.074	+3.464	<.001	.005	3	3
UCEC	RNU7-29P →	+0.104	+2.513	<.001	.004	3	3
GBM	RNA5SP172 →	+0.532	+6.189	<.001	.001	3	2
GBM	IGLV3-22 →	+0.877	+5.352	<.001	.005	3	2
LGG	SLC16A1P1 →	+0.032	+4.478	.001	.005	3	2
PRAD	GDF2 →	+0.076	+5.000	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,487 associations by consensus.

RPL23AP39 by GCNA expression — CESC

Explore this box plot interactively →