GCNA

Across TCGA patient cohorts, GCNA mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GCNA-associated genes across cancer lineages are eEF2, EGFR_pY1068, and A-Raf_pS299. Each is linked with GCNA in more than 2 cancer types. Because this analysis shows association rather than direction, both GCNA-to-partner and partner-to-GCNA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by GCNA-low versus GCNA-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GCNA→partner) and Y-score (partner→GCNA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	eEF2 →	+0.581	+2.815	<.001	.036	3	2
UCEC	EGFR_pY1068 →	-0.303	-2.222	<.001	<.001	3	2
UCEC	A-Raf_pS299 →	-0.105	-1.502	.004	.027	3	2
UCEC	PCNA →	+0.224	+2.137	<.001	<.001	3	2
UCEC	Shc_pY317 →	-0.185	-1.700	<.001	.001	3	2
UCEC	TFRC →	+0.434	+1.473	.007	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

eEF2 by GCNA expression — COAD

Explore this box plot interactively →