GCNA

Across TCGA cell cohorts, GCNA RNA expression is significantly associated with the go_rna of many other GO terms, with 3,074 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible GCNA-associated GO terms across cancer lineages are mRNA splice site recognition, Late viral transcription, and Regulation of translational initiation. Each is linked with GCNA in more than 12 cancer types. Because this analysis shows association rather than direction, both GCNA-to-partner and partner-to-GCNA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mRNA splice site recognition grouped by GCNA-low versus GCNA-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GCNA→partner) and Y-score (partner→GCNA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	mRNA splice site recognition →	+0.156	+0.773	<.001	<.001	3	13
BONE	Late viral transcription →	+0.135	+0.767	.002	<.001	3	12
BLOOD_Lymphoma	Regulation of translational initiation →	+0.067	+0.576	<.001	<.001	3	11
CNS	Protein localization to vacuole →	+0.055	+0.614	.002	.001	3	11
BLOOD_Leukemia	Nucleic acid catabolic process →	+0.049	+0.549	<.001	<.001	3	11
LARGE_INTESTINE	Regulation of protein autoubiquitination →	+0.139	+0.737	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,074 associations by consensus.

mRNA splice site recognition by GCNA expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →