GCNA

Across TCGA cell cohorts, GCNA mutation is significantly associated with the RNA expression of many other genes, with 55 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GCNA-associated genes across cancer lineages are P2RY13, OR13C3, and ZC3H12B. Each is linked with GCNA in more than 1 cancer types. Because this analysis shows association rather than direction, both GCNA-to-partner and partner-to-GCNA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, P2RY13 grouped by GCNA-low versus GCNA-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GCNA→partner) and Y-score (partner→GCNA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	P2RY13 →	+0.017	+4.312	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR13C3 →	+0.017	+4.472	<.001	.001	3	1
LARGE_INTESTINE	ZC3H12B →	+0.473	+3.364	.001	.002	3	1
LARGE_INTESTINE	CYTIP →	+1.135	+3.237	.004	.003	3	1
LARGE_INTESTINE	SLC25A28 →	+0.445	+3.364	.004	.002	3	1
LARGE_INTESTINE	KCNV1 →	+1.023	+3.364	.002	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

P2RY13 by GCNA expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →