GCN1

Across TCGA pan-cancer cohorts, GCN1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated GCN1 data layer compared with 26 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher GCN1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated GCN1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

CCRCC, LUAD, and LSCC are the cancer types where GCN1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Tertile	All	0.544	1.000	.005	22	view →
LUAD	OS	Median	II,III,IV	1.000	0.862	.004	15	view →
LSCC	DFS	Tertile	All	1.000	0.916	.009	11	view →
HNSC	DFS	Quartile	II,III,IV	0.872	0.578	.017	9	view →
UCEC	DFS	Tertile	III,IV	1.000	0.529	.049	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

GCN1–CCRCC (OS)

Open the CCRCC breakdown →