GCN1

Across TCGA cell cohorts, GCN1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,360 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible GCN1-associated GO terms across cancer lineages are Negative regulation of gene expression, epigenetic, Nucleic acid transport, and RNA transport. Each is linked with GCN1 in more than 16 cancer types. Because this analysis shows association rather than direction, both GCN1-to-partner and partner-to-GCN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of gene expression, epigenetic grouped by GCN1-low versus GCN1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GCN1→partner) and Y-score (partner→GCN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Negative regulation of gene expression, epigenetic →	+0.093	+1.097	<.001	<.001	3	17
OESOPHAGUS	Nucleic acid transport →	+0.123	+0.840	<.001	.002	3	17
OESOPHAGUS	RNA transport →	+0.123	+0.840	<.001	.002	3	17
BONE	Regulation of transcription by RNA polymerase I →	+0.116	+0.837	<.001	<.001	3	16
BONE	RNA localization →	+0.130	+0.934	<.001	<.001	3	16
SOFT_TISSUE	Nucleic acid catabolic process →	+0.064	+1.158	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,360 associations by consensus.

Negative regulation of gene expression, epigenetic by GCN1 expression — BONE

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