GCN1

Across TCGA cell cohorts, GCN1 mutation is significantly associated with the RNA expression of many other genes, with 1,177 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GCN1-associated genes across cancer lineages are CDKN1B, MDGA2, and OR51B2. Each is linked with GCN1 in more than 2 cancer types. Because this analysis shows association rather than direction, both GCN1-to-partner and partner-to-GCN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDKN1B grouped by GCN1-low versus GCN1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GCN1→partner) and Y-score (partner→GCN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CDKN1B →	+0.643	+2.265	.003	.001	3	3
BLOOD_Lymphoma	MDGA2 →	+0.252	+3.717	<.001	.005	3	2
BLOOD_Lymphoma	OR51B2 →	+0.342	+2.874	<.001	.009	3	2
LUNG_SCLC	SIRPD →	+0.065	+5.029	<.001	.006	3	2
BLOOD_Leukemia	PYGL →	-3.100	-3.459	<.001	.002	3	2
BLOOD_Leukemia	BCL11B →	+1.619	+3.544	.002	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,177 associations by consensus.

CDKN1B by GCN1 expression — LARGE_INTESTINE

Explore this box plot interactively →