GCN1

Across TCGA cell cohorts, GCN1 mutation is significantly associated with the mutation status of many other genes, with 5,271 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GCN1-associated genes across cancer lineages are ALK, UBR5, and IRS1. Each is linked with GCN1 in more than 5 cancer types. Because this analysis shows association rather than direction, both GCN1-to-partner and partner-to-GCN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ALK grouped by GCN1-low versus GCN1-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GCN1→partner) and Y-score (partner→GCN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ALK →	+4.857	+4.297	.009	.009	1	6
OVARY	UBR5 →	+2.933	+2.397	.003	.003	1	6
SKIN	IRS1 →	+3.604	+2.532	.001	.001	1	6
LIVER	SPTB →	+4.108	+4.108	.005	.005	1	5
URINARY_TRACT	PGAP6 →	+4.307	+3.672	.004	.004	1	5
SOFT_TISSUE	TDRD6 →	+5.502	+5.502	.003	.003	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,271 associations by consensus.

ALK by GCN1 expression — BREAST

Explore this box plot interactively →