GCM2

Across TCGA cell cohorts, GCM2 mutation is significantly associated with the RNA expression of many other genes, with 173 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GCM2-associated genes across cancer lineages are OCM2, VSX2, and C20orf85. Each is linked with GCM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GCM2-to-partner and partner-to-GCM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OCM2 grouped by GCM2-low versus GCM2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GCM2→partner) and Y-score (partner→GCM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OCM2 →	+0.045	+5.662	<.001	.002	3	2
BLOOD_Leukemia	VSX2 →	+0.032	+4.258	<.001	.002	3	1
BLOOD_Leukemia	C20orf85 →	+0.033	+4.384	<.001	.006	3	1
BLOOD_Leukemia	CST8 →	+0.037	+4.384	<.001	.006	3	1
BLOOD_Leukemia	DEFB108B →	+0.195	+4.269	<.001	.002	3	1
BLOOD_Leukemia	GRIN2B →	+0.188	+4.133	.003	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 173 associations by consensus.

OCM2 by GCM2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →