GCM1

Across TCGA pan-cancer cohorts, GCM1 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated GCM1 data layer compared with 22 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher GCM1 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated GCM1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

UCEC, COAD, and SKCM are the cancer types where GCM1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	1.000	0.828	.013	18	view →
COAD	OS	Median	All	0.168	0.806	.002	12	view →
SKCM	DFS	Median	III,IV	1.000	0.491	.030	5	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

GCM1–UCEC (DFS)

Open the UCEC breakdown →