GCM1

Across TCGA patient cohorts, GCM1 mutation is significantly associated with the RNA expression of many other genes, with 2,948 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GCM1-associated genes across cancer lineages are OR10S1, MIR181C, and ANP32B. Each is linked with GCM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GCM1-to-partner and partner-to-GCM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10S1 grouped by GCM1-low versus GCM1-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GCM1→partner) and Y-score (partner→GCM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	OR10S1 →	+0.047	+4.539	<.001	.008	3	2
CESC	MIR181C →	+0.903	+4.934	<.001	.002	3	2
SKCM	ANP32B →	+0.530	+3.491	.007	.002	3	2
SKCM	ZNF510 →	+0.616	+3.465	.009	.003	3	2
UCEC	CWC25 →	+0.490	+2.695	<.001	<.001	3	2
UCEC	AATF →	+0.422	+2.864	.002	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,948 associations by consensus.

OR10S1 by GCM1 expression — CESC

Explore this box plot interactively →