GCM1

Across TCGA patient cohorts, GCM1 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GCM1-associated genes across cancer lineages are eEF2, EGFR_pY1068, and eIF4E. Each is linked with GCM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GCM1-to-partner and partner-to-GCM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by GCM1-low versus GCM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GCM1→partner) and Y-score (partner→GCM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.372	+1.584	.008	.036	3	1
UCEC	EGFR_pY1068 →	-0.261	-2.700	.008	.006	3	1
UCEC	eIF4E →	+0.218	+3.169	.008	<.001	3	1
UCEC	FoxM1 →	+0.258	+3.594	.011	.001	3	1
UCEC	GATA6 →	-0.125	-2.584	.039	.010	3	1
UCEC	JNK2 →	+0.276	+2.502	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

eEF2 by GCM1 expression — UCEC

Explore this box plot interactively →