GCM1

Across TCGA cell cohorts, GCM1 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,201 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GCM1-associated GO terms across cancer lineages are Negative regulation of response to endoplasmic reticulum stress, Negative regulation of intrinsic apoptotic signaling pathway, and Protein localization to endoplasmic reticulum. Each is linked with GCM1 in more than 5 cancer types. Because this analysis shows association rather than direction, both GCM1-to-partner and partner-to-GCM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of response to endoplasmic reticulum stress grouped by GCM1-low versus GCM1-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GCM1→partner) and Y-score (partner→GCM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Negative regulation of response to endoplasmic reticulum stress →	+0.108	+0.096	.005	.004	3	6
LUNG_SCLC	Negative regulation of intrinsic apoptotic signaling pathway →	+0.070	+0.163	<.001	.002	3	6
BLOOD_Lymphoma	Protein localization to endoplasmic reticulum →	+0.082	+0.068	<.001	.002	3	6
LUNG_SCLC	Positive regulation of telomere maintenance →	+0.073	+0.186	<.001	.002	3	5
BLOOD_Leukemia	Macroautophagy →	+0.025	+0.088	.003	.005	3	5
BLOOD_Leukemia	Positive regulation of DNA-templated transcription, elongation →	+0.031	+0.114	.005	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,201 associations by consensus.

Negative regulation of response to endoplasmic reticulum stress by GCM1 expression — PANCREAS

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