GCM1

Across TCGA cell cohorts, GCM1 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. CNS shows the largest number of these associations.

The most reproducible GCM1-associated genes across cancer lineages are OR1L3, DPRX, and OR10V1. Each is linked with GCM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GCM1-to-partner and partner-to-GCM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1L3 grouped by GCM1-low versus GCM1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GCM1→partner) and Y-score (partner→GCM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR1L3 →	+0.032	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	DPRX →	+0.273	+5.228	<.001	.005	3	1
CNS	OR10V1 →	+0.023	+4.285	<.001	.001	3	1
CNS	PRORY →	+0.472	+4.044	.001	.003	3	1
CNS	PRR30 →	+0.014	+3.643	<.001	.007	3	1
LARGE_INTESTINE	PROKR2 →	+0.012	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

OR1L3 by GCM1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →