GCLM

Across TCGA patient cohorts, GCLM RNA expression is significantly associated with the protein abundance of many other proteins, with 13,170 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible GCLM-associated proteins across cancer lineages are G6PD, TXNRD1, and PGD. Each is linked with GCLM in more than 5 cancer types. Because this analysis shows association rather than direction, both GCLM-to-partner and partner-to-GCLM results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GCLM versus G6PD in LSCC, with a Pearson correlation of 0.78.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (GCLM→partner) and Y-score (partner→GCLM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	G6PD →	+0.895	+1.949	<.001	<.001	3	6
LSCC	TXNRD1 →	+0.770	+1.713	<.001	<.001	3	5
LSCC	PGD →	+0.722	+1.694	<.001	<.001	3	5
LSCC	AKR1C1 →	+1.875	+1.766	<.001	<.001	3	5
LSCC	UGT1A6 →	+1.149	+1.495	<.001	<.001	3	4
PDAC	ACACA_S80 →	+0.627	+0.418	.006	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,170 associations by consensus.

GCLM vs G6PD — LSCC

Explore this scatter interactively →